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RENAL CELL CARCINOMA MIB-1, BAX AND BCL-2 EXPRESSION AND PROGNOSIS

โœ Scribed by KALLIO, J; HIRVIKOSKI, P; HELIN, H; LUUKKAALA, T; TAMMELA, T; KELLOKUMPULEHTINEN, P; MARTIKAINEN, P

Book ID
123228224
Publisher
Lippincott Williams and Wilkins
Year
2004
Tongue
English
Weight
395 KB
Volume
172
Category
Article
ISSN
0022-5347

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Bcl-2 is a proto-oncogene which is involved in prolonging cell survival by inhibiting programmed cell death. Bax and bcl-x are members of the bcl-2 family; when overexpressed, they can counteract the ability of bcl-2 to inhibit apoptosis. This suggests a model in which the ratios of bcl-2 to bax and