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716 MIB 1, BAX and BCL-2 expression and prognosis in renal cell carcinoma

โœ Scribed by J. Kallio; P. Hirvikoski; H. Helin; T. Luukkaala; T. Tammela; P. Kellokumpu-Lehtinen; P. Martikainen

Book ID
118645920
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
217 KB
Volume
3
Category
Article
ISSN
1569-9056

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Bcl-2 is a proto-oncogene which is involved in prolonging cell survival by inhibiting programmed cell death. Bax and bcl-x are members of the bcl-2 family; when overexpressed, they can counteract the ability of bcl-2 to inhibit apoptosis. This suggests a model in which the ratios of bcl-2 to bax and