Removal and Inactivation of Hepatitis A Virus (HAV) during Processing of Factor VIII Concentrates
β Scribed by Dr. J. Hamman; J. Zou; B. Horowitz
- Book ID
- 115110087
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 430 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0042-9007
No coin nor oath required. For personal study only.
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## Abstract Recent reports have suggested an increased risk of type A viral hepatitis in hemophilic patients treated with high purity factor VIII concentrates prepared using ion exchange chromatography coupled with solvent/detergent treatment for inβactivation of viruses. To determine the capacity
Chromatography with a solid-phase polyelectrolyte based on ethylene maleic anhydride polyelectrolyte (EMA PE) has been shown to remove a large proportion of hepatitis B surface antigen (HBsAg), including hepatitis B virus (HBV) particles, from contaminated cryoprecipitate. This process may reduce th