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Remnants of Albunex® nucleate acoustic cavitation

✍ Scribed by Diane Dalecki; Carol H. Raeman; Sally Z. Child; David P. Penney; Edwin L. Carstensen

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
936 KB
Volume
23
Category
Article
ISSN
0301-5629

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✦ Synopsis

Mice were injected with 0.1 mL Albunex@ and exposed to 200 pulses from a piezoelectric lithotripter at times ranging from 5 min to 24 h following injection. Each pulse was approximately 1.5 sinusoidal oscillations at a fundamental frequency of -0.1 MHz with pressure amplitude of -2 MPa. Although the contrast agent ceases to be an effective scatterer of diagnostic ultrasound after a few minutes in the circulation, the modest lithotripter exposures caused significant hemorrhaging in bladder, mesentery and intestine for periods of up to 4 h after injection. The results demonstrate either that highly stable bubbles much smaller than resonance size or air-containing fragments of the shells of Albunex@ serve as effective nuclei for acoustic cavitation. 0 1997 World Federation for Ultrasound in Medicine & Biology.

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✍ Andrew A. Brayman; Morton W. Miller 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 407 KB

The hypothesis tested was that gas bodies capable of nucleating violent cavitation activity in vitro would survive the rapid disruption of Albunex" microspheres by l-MHz ultrasound. Human erythrocyte hemolysis was used as a proxy measure of cavitation. Fluid (5% human serum albumin [HSA]) with or wi