Acoustic cavitation nuclei survive the apparent ultrasonic destruction of Albunex® microspheres
✍ Scribed by Andrew A. Brayman; Morton W. Miller
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 407 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0301-5629
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✦ Synopsis
The hypothesis tested was that gas bodies capable of nucleating violent cavitation activity in vitro would survive the rapid disruption of Albunex" microspheres by l-MHz ultrasound. Human erythrocyte hemolysis was used as a proxy measure of cavitation. Fluid (5% human serum albumin [HSA]) with or without Albunex" (ALX) was exposed or sham-exposed to l-MI-Ix ultrasound (P' = 1.25 -+ 0.01 MPa, P-= 0.81 + 0.01 MPa; Zsprp -35 W/cm') for 60 s using 10-w pulses and a duty factor of 0.5. An equal volme of whole human blood was then added to the fluid, followed by a second 60-s treatment. Iusonation of ceil suspensions prepared in previously sham-exposed HSA + ALX fluid produced about 4% hemdysis, a level significantly greater than in the controls. Insonation of cell suspensions prepared in previously insonated HSA + ALX fluid produced about 0.4% hemoiysis; this also diiered sign~tly from the controls. The dam thus support the hypothesis. 0 1997 World Federation for Ultrasound in Medicine and Biology.