Remediation of attentional dysfunction in rats with lesions of the medial prefrontal cortex by intra-accumbens administration of the dopamine D2/3receptor antagonist sulpiride

Chronic haloperidol administration incre

Chronic haloperidol administration increases the density of D2 dopamine receptors in the medial prefrontal cortex of the rat

✍ A. John MacLennan; Stella Atmadja; Nancy Lee; H. C. Fibiger 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 299 KB

Rats received haloperidol (1.3-1.5 mg/kg/day) via their drinking water for 21 weeks. At the end of this period the density of D2 dopamine receptors and their affinity for [3H]-spiperone were measured in the striatum and medial prefrontal cortex. The chronic haloperidol treatment increased the densit