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Remarks on the rate of formation of bisulfite ions in aqueous solution

✍ Scribed by Siegfried Beilke; Dennis Lamb

Publisher
American Institute of Chemical Engineers
Year
1975
Tongue
English
Weight
378 KB
Volume
21
Category
Article
ISSN
0001-1541

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The instability of vancomycin, a glycopeptide antibiotic, limits its shelf-life because the deamidation of its asparagine residue results in the formation of a zwitterion with limited aqueous solubility. Analysis of the pH-rate profile for vancomycin indicates that the deamidation reaction is notabl