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Remarkable stability of derivatives of leucomitomycin F. Novel mitomycin analogs

โœ Scribed by Egbertson, Melissa; Danishefsky, Samuel J.; Schulte, Gayle


Book ID
125969172
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
645 KB
Volume
52
Category
Article
ISSN
0022-3263

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The synthesis, antibacterial activity and DHP-susceptibility of a series of novel 2-vinyl carbapenems is described. Carbapenems having a 1'-substituted vinyl moiety at the 2 position were found to be very stable toward DHP-1, displaying comparable stability to compounds with a 1 ~-methyl functionali