Background: Epiluminescence microscopy (ELM) is a noninvasive clinical tool recently developed for the diagnosis of pigmented skin lesions (PSLs), with the aim of improving melanoma screening strategies. However, the complexity of the ELM grading protocol means that considerable expertise is require
Reliability of computer image analysis of pigmented skin lesions of Australian adolescents
✍ Scribed by Joanne F. Aitken; John Pfitzner; Diana Battistutta; Peter K. O'Rourke; Adèle C. Green; Nicholas G. Martin
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 499 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
BACKGROUND.
The diagnosis of melanomas at an early stage is associated with improved :;urvival, so the recognition of changes in pigmented skin lesions over time is important. We have developed a computer imaging system with the aim of assisting clinicians in differentiating early melanomas from benign pigmented skin lesions. The objective of this study was to investigate the system's reliability over time in measuring diagnostic characteristics of pigmented skin lesions, including their color, size, shape, and distinctness of boundary.
METHODS.
We captured video images of 5 lesions, all larger than 2 mm in greatest dimension, on each of 66 Australian adolescents on 2 occasions approximately 1 month apart. Features extracted by computer image analysis included area, perimeter, and regularity of outline of the lesions, the mean and standard deviation of reflectance at red, green, and blue wavelengths, and the mean and standard deviation of the gradients of red, green, and blue reflectance at the lesion boundary.
RESULTS.
Ad1 measurements showed moderate to high reliability (intraclass correlation coefficients 0.66-0.941, except for the standard deviations of the color gradients, whose reliability improved to moderate levels (0.68-0.71) when the mean of 5 lesions was considered. For most outcomes, reasonable within subject reliability was achieved when five lesions per subject were measured.
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