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Reliability of behavioral analyses in a partial lesion rat model of Parkinson's disease in relation to nigrostriatal dopaminergic depletion

✍ Scribed by Yoichiro Kikuchi; Takao Yasuhara; Takashi Agari; Satoshi Kuramoto; Akihiko Kondo; Masahiro Kameda; Tomohito Kadota; Tanefumi Baba; Naoki Tajiri; Feifei Wang; Hanbai Liang; Judith T. Tayra; Aiko Shinkou; Yasuyuki Miyoshi; Isao Date

Book ID
116777880
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
69 KB
Volume
68
Category
Article
ISSN
0168-0102

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## Abstract Increased oxidative stress contributes to pathogenesis of Parkinson's disease (PD). 8‐hydroxy‐2'‐deoxyguanosine (8‐OHdG) is the oxidation product most frequently measured as an indicator of oxidative DNA damage. Several studies have shown increased 8‐OHdG in PD patients. There are few b