Relevance of Ki-67 expression in the classification of non-Hodgkin's lymphomas: a morphometric and double-immunostaining study
β Scribed by A. HOUMAND; B. ABRAHAMSEN; N. TINGGAARD PEDERSEN
- Book ID
- 108778232
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 628 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0309-0167
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## Abstract Expression of Kiβ67, a nuclear antigen protein present in all cycling cells, is used to determine the growth fraction of tumors. The aim of this study was to evaluate the role and prognostic significance of the Kiβ67 proliferation index (PI) in nonβHodgkin's lymphoma. Kiβ67 was assayed
Cell size and mitotic indices were studied in 243 nonHodgkin 's lymphomas (NHL) diagnosed cytologically and classijied according to the Working Formulation. LOW; intermediate-, and highgrade lymphomas constituted 14.8%. 18.9%, and 61.7% of the cases, respectively. Measurement of the diameter of 100