Working formulation of the non-Hodgkin's lymphomas: A study of cell size and mitotic indices in cytologic subtypes

✍ Scribed by Dr. Dilip K. Das; Subhash K. Gupta; Bhoopendra N. Datta; Suresh C. Sharma

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 469 KB
• Volume: 7
• Category: Article
• ISSN: 8755-1039
• DOI: 10.1002/dc.2840070511

✦ Synopsis

Cell size and mitotic indices were studied in 243 nonHodgkin 's lymphomas (NHL) diagnosed cytologically and classijied according to the Working Formulation. LOW; intermediate-, and highgrade lymphomas constituted 14.8%. 18.9%, and 61.7% of the cases, respectively. Measurement of the diameter of 100 lymphoid cells in each case showed that in most of the low-grade malignant lymphomas, 50-80% of the cells were small (< 10 pm). A majority of the cells (an average of 4.540%) in intermediate-and high-grade lymphomas were in the range of 11-15 pm. Only the intermediate-grade large noncleaved and high-grade immunoblastic lymphomas had a majority of their cells (> 50%) larger than 15 pm. The mitotic indices (number of mitotic figures per 500 lymphoid cells) showed a highly signijicant difference between low-(0.7+1.14), intermediate -(3.0k2.67). and high-grade (5.4k3.441 lymphomas using the Wilcoxon's signed rank test (P < 0.0001). Nearly two-thirds of the cases in each grade were within specific ranges of mitotic indices, i.e.,