Release of ibuprofen from poly(ε-caprolactone-co-D,L-lactide) and simulation of the release
✍ Scribed by Niina Ahola; Jaana Rich; Teija Karjalainen; Jukka Seppälä
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 154 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0021-8995
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Copolymers of -caprolactone and L-lactide (PCLLA) with different monomer ratio were synthesized by ring opening polymerization, and drug-loaded nanoparticles of poly--caprolactone (PCL), poly-L-lactide (PLLA), and their copolymers were prepared by precipitation method, respectively. The results of d
## Abstract 5‐Fluorouracil (5‐Fu) loaded poly(glycolide‐__co__‐lactide‐__co__‐caprolactone) (PGLC) nanoparticles were prepared by modified spontaneous emulsification solvent diffusion method (modified‐SESD method) and characterized by dynamic light scattering, scanning electron microscopy and ^1^H
## Abstract Fourier transform infrared (FTIR) spectroscopy was used to reveal intermolecular interactions between carbon dioxide (CO~2~) and the carbonyl groups of poly(L‐lactide) (PLLA), poly(D,L‐lactide) (PDLLA), and poly(ε‐caprolactone) (PCL). After exposing polymer films to high pressure CO~2~,