Hydroxyapatite (HA) coated liposomes (HACL) have been successfully manufactured and filled with a model hydrophobic (lipophilic) drug, indomethacin (IMC). These HACL particles have been characterized in terms of particle size and z-potential. The liposomes are formed from 1,2-dimyristoyl-sn-glycero-
Release of encapsulated proteinase from dehydration-rehydration liposomes by a co-encapsulated phospholipase
✍ Scribed by Antonia Picón; Pilar Gaya; Margarita Medina; Manuel Nuñez
- Publisher
- Springer Netherlands
- Year
- 1995
- Tongue
- English
- Weight
- 342 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0141-5492
No coin nor oath required. For personal study only.
✦ Synopsis
Bacillus subtilis neutral proteinase was encapsulated in conventional dehydrationrehydration liposomes and, co-encapsulated with a phospholipase, in triggered liposomes. Triggered liposomes had released in buffer 58.0% of the encapsulated proteinase after 180 min at 30°C, whereas only 1.1% was released from conventional liposomes. Addition of triggered liposomes to milk resulted in only 70.4% residual 13casein after 240 min at 30°C compared to 90.7% in control milk. If triggered liposomes were added to milk with lactic starter and rennet, residual 13-casein was only 52.3% after 240 min, compared to 80.3% in milk without liposomes.
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