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Release of Ca2+ from the sarcoplasmic reticulum increases mitochondrial [Ca2+] in rat pulmonary artery smooth muscle cells

✍ Scribed by Robert M. Drummond; Richard A. Tuft

Book ID
111118826
Publisher
Cambridge University Press
Year
1999
Tongue
English
Weight
398 KB
Volume
516
Category
Article
ISSN
0022-3751

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Ca2+ release from skeletal sarcoplasmic reticulum (SR) could be regulated by at least three mechanisms: 1) Ca2+, 2) calmodulin, and 3) Ca2+/calmodulin-dependent phosphorylation. Bell-shaped Ca(2+)-dependence of Ca2+ release from both actively- and passively-loaded SR vesicles suggest that opening an