Ryanodine is a neutral plant alkaloid which functions as a probe for an intracellular Ca2+ release channel (ryanodine receptor) in excitable tissues. Using [3H]ryanodine, a 30 S protein complex comprised of four polypeptides of Mr 565,000 has been isolated and functionally reconstituted into planar
Functional characterization of the Ca2+-gated Ca2+release channel of vascular smooth muscle sarcoplasmic reticulum
โ Scribed by Annegret Herrmann-Frank; Edward Darling; Gerhard Meissner
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 1003 KB
- Volume
- 418
- Category
- Article
- ISSN
- 0031-6768
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Annexin VI has eight highly conserved repeated domains; all other annexins have four. Diaz-Muiioz et al. ( J Biol Chem 265:15894, 1990) reported that annexin VI alters the gating properties of the ryanodine-sensitive Ca2+-release channel isolated from sarcoplasmic reticulum. To investigate the domai