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Relaxivity of gadolinium complexes detected by atomic magnetometry

✍ Scribed by David J. Michalak; Shoujun Xu; Thomas J. Lowery; C. W. Crawford; Micah Ledbetter; Louis-S. Bouchard; David E. Wemmer; Dmitry Budker; Alexander Pines

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
281 KB
Volume
66
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Laser atomic magnetometry is a portable and low‐cost yet highly sensitive method for low magnetic field detection. In this work, the atomic magnetometer was used in a remote‐detection geometry to measure the relaxivity of aqueous gadolinium‐diethylenetriamine pentaacetic acid Gd(DTPA) at the Earth's magnetic field (40 μT). The measured relaxivity of 9.7 ± 2.0 s^−1^ mM^−1^ is consistent with field‐cycling experiments measured at slightly higher magnetic fields, but no cryogens or strong and homogeneous magnetic field were required for this experiment. The field‐independent sensitivity of 80 fT Hz^–1/2^ allowed an in vitro detection limit of ∼ 10 μM Gd(DTPA) to be measured in aqueous buffer solution. The low detection limit and enhanced relaxivity of Gd‐containing complexes at Earth's field motivate continued development of atomic magnetometry toward medical applications. Magn Reson Med 66:603–606, 2011. © 2011 Wiley‐Liss, Inc.

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