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Relaxation of IGF2 imprinting in Wilms tumours associated with specific changes in IGF2 methylation

✍ Scribed by Sullivan, Michael J; Taniguchi, Takanobu; Jhee, Agnes; Kerr, Natalie; Reeve, Anthony E

Book ID
110062472
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
402 KB
Volume
18
Category
Article
ISSN
0950-9232

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## Abstract The __WT1__ gene essential for the embryonic kidney development is mutated in 15–25% of Wilms tumors (WTs). To clarify whether genetic subtypes of __WT1__ abnormalities are correlated with __IGF2__ or __CTNNB1__ alterations or clinicopathological characteristics, we performed comprehens