Big Blue@ (BB) and generic B6C3F1 mice were given one to three i.p. injections of 50 mg/kg benzo[a]pyrene (B[a]P) in DMSO every other day to achieve cumulative doses of 50 to 150 mg/kg. Three weeks after treatment, the mutation frequency at the endogenous hprt gene and lac/ transgene was measured in
✦ LIBER ✦
Relative sensitivity of the endogenous hprt gene and lacl transgene in ENU-treated big blue™ B6C3F1 mice
✍ Scribed by Thomas R. Skopek; Kristy L. Kort; Deborah R. Marino
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 653 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0893-6692
No coin nor oath required. For personal study only.
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Carolina 1,3-Butadiene (BD) is a carcinogen that is bioactivated to at least two genotoxic metabolites. In the present article, we review briefly our previous studies on the in vivo mutagenicity and mutational spectra of BD in bone marrow and extend these studies to examine the effect of exposure ti