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Relative Contribution of CYP3A to Amitriptyline Clearance in Humans: In Vitro and In Vivo Studies

✍ Scribed by Venkatakrishnan, Karthik; Schmider, Jürgen; Harmatz, Jerold S.; Ehrenberg, Bruce L.; von Moltke, Lisa L.; Graf, Jennifer A.; Mertzanis, Polyxane; Corbett, Kathleen E.; Rodriguez, Molly C.; Shader, Richard I.; Greenblatt, David J.

Book ID
125441670
Publisher
Sage Publications
Year
2001
Tongue
English
Weight
130 KB
Volume
41
Category
Article
ISSN
0091-2700

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We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants. Good correlations were observed between the intrinsic clearance (CL int ) for 4-hydroxylation and CYP3A4 content and between the CL int for a