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Relative Concentrations of Proton MR Visible Neurochemicals in Gray and White Matter in Human Brain

✍ Scribed by Timothy J. Doyle; Barry J. Bedell; Ponnada A. Narayana

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
958 KB
Volume
33
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The relative distributions of N‐acetylaspartate (NAA) + N‐acetylaspartylglutamate (NAAG), creatine + phosphocreatine (Cr/PCr), and choline (Cho) in the gray and white matter of human brain were determined by utilizing proton magnetic resonance spectroscopic imaging (SI). The SI data was processed using an automated spectroscopic image processing algorithm, and image segmentation was performed using a supervised technique. Linear regression analysis indicated that the NAA + NAAG (2.01 ppm) and Cr/PCr (3.02 ppm) peaks are greater in gray matter compared with white matter. The large intersubject variation observed in the Cho (3.20 ppm) resonance prevented the assessment of its regional distribution with confidence.

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