✦ LIBER ✦

Differentiation of metabolic concentrations between gray matter and white matter of human brain by in vivo1H magnetic resonance spectroscopy

✍ Scribed by Yonker Wang; Shi-Jiang Li

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 684 KB
Volume: 39
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910390107

No coin nor oath required. For personal study only.

✦ Synopsis

Differentiation of absolute metabolite concentrations between gray and white matter in the occipital region of normal human brain was performed by in vivo localized single-voxel 1H magnetic resonance spectroscopy at 1.5 Tesla with long echo time (136 ms). With the combination of image segmentation between white and gray matter and cerebrospinal fluid, signal compensation of T1 and T2 effects, tissue water signal as the internal concentration reference, as well as compensation by different water contents in gray and white matters, it was determined that the levels of N-acetylaspartate (NAA), creatine and/or phosphocreatine (Cr), and choline-containing compounds (Cho) in gray matter were significantly higher than in white matter. The averaged NAA, Cr, and Cho concentrations in gray matter were 11.0, 9.7, and 1.9 mM/liter, respectively, in comparison with 7.5, 5.2, and 1.6 mM/liter in white matter. These results suggest that precise composition of white and gray matter and cerebrospinal fluid is necessary to avoid partial voluming effect in a single voxel and to accurately quantify the metabolite concentrations.

📜 SIMILAR VOLUMES

Proton magnetic resonance spectroscopy o

Proton magnetic resonance spectroscopy of human brain: Applications to normal white matter, chronic infarction, and MRI white matter signal hyperintensities

✍ Dominique Sappey-Marinier; Giovanna Calabrese; Hoby P. Hetherington; Sarah N. G. 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 831 KB

## Abstract A modified ISIS method, for image‐selected localized proton magnetic resonance spectroscopy (^1^H MRS), was used to determine the ratios and __T__~2~ relaxation times of proton metabolites in normal subjects and in patients with chronic infarction and MRI white matter signal hyperintens

Metabolic profiles of human brain tumors

Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy

✍ F.A. Howe; S.J. Barton; S.A. Cudlip; M. Stubbs; D.E. Saunders; M. Murphy; P. Wil 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 252 KB 👁 1 views

## Abstract Proton spectroscopy can noninvasively provide useful information on brain tumor type and grade. Short‐ (30 ms) and long‐ (136 ms) echo time (TE) ^1^H spectra were acquired from normal white matter (NWM), meningiomas, grade II astrocytomas, anaplastic astrocytomas, glioblastomas, and met

Relative Concentrations of Proton MR Vis

Relative Concentrations of Proton MR Visible Neurochemicals in Gray and White Matter in Human Brain

✍ Timothy J. Doyle; Barry J. Bedell; Ponnada A. Narayana 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 958 KB

## Abstract The relative distributions of __N__‐acetylaspartate (NAA) + __N__‐acetylaspartylglutamate (NAAG), creatine + phosphocreatine (Cr/PCr), and choline (Cho) in the gray and white matter of human brain were determined by utilizing proton magnetic resonance spectroscopic imaging (SI). The SI

Inverse T2 contrast at 1.5 Tesla between

Inverse T2 contrast at 1.5 Tesla between gray matter and white matter in the occipital lobe of normal adult human brain

✍ Jinyuan Zhou; Xavier Golay; Peter C.M. van Zijl; M. Johanna Silvennoinen; Risto 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 196 KB 👁 1 views

## Abstract __T__~2~ of cortical gray matter is generally assumed to be longer than that of white matter. It is shown here that this is not the case in the occipital lobe, but that this effect is often obscured at lower resolution and concealed in standard __T__~2~‐weighted images. Using a high‐res

High spatial resolution 1H-MRSI and segm

High spatial resolution 1H-MRSI and segmented MRI of cortical gray matter and subcortical white matter in three regions of the human brain

✍ Susan M. Noworolski; Sarah J. Nelson; Roland G. Henry; Mark R. Day; Lawrence L. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 271 KB 👁 3 views

High-resolution MR imaging and spectroscopic imaging were used to study differences in proton spectra between cortical gray matter and subcortical white matter in 23 normal volunteers using a 1.5 T scanner and surface coil receivers. A point-resolved spectroscopy (PRESS) volume with an 8 x 8 x 8 pha

Assessment of absolute metabolite concen

Assessment of absolute metabolite concentrations in human tissue by 31P MRS in vivo. Part I: Cerebrum, cerebellum, cerebral gray and white matter

✍ Reto Buchli; Corinne O. Duc; Ernst Martin; Peter Boesiger 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 652 KB

## Abstract Absolute metabolite concentrations were determined in four different brain regions using phosphorus magnetic resonance spectroscopy (^31^P MRS) on 10 healthy adult volunteers. Localized spectra were collected simultaneously from the cerebellum and the cerebrum and, later, from deep whit