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Relative absorption of the two enantiomers of terbutaline after duodenal administration

✍ Scribed by L. Borgström; B. -M. Kennedy; B. Nilsson; B. Angelin

Book ID
104700525
Publisher
Springer
Year
1990
Tongue
English
Weight
259 KB
Volume
38
Category
Article
ISSN
0031-6970

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✦ Synopsis

The absorption of the two enantiomers of terbutaline, (+)-terbutaline and (-)-terbutaline, and of the racemate, (+/-)-terbutaline, has been studied in six healthy volunteers using a newly developed intestinal perfusion technique. The area under the plasma concentration curve for the (-)-enantiomer was more than twice that for the (+)-enantiomer. The data demonstrate a clear difference in absorption efficiency between (-)- and (+)-terbutaline, but further studies are required to establish whether (-)-terbutaline influences the absorption of (+)-terbutaline.

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