Relationships between chromatographic properties, partition data and chemical structure of o-alkyl-o-arylphenylphosphonothioates

✍ Scribed by W. Steurbaut; W. Dejonckheere; R.H. Kips

• Publisher: Elsevier Science
• Year: 1978
• Tongue: English
• Weight: 751 KB
• Volume: 160
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(00)91779-5

✦ Synopsis

A series of 0-alkyl-0-arylphenylphosphonothioates were synthesized and their partition coefficients and the corresponding RF values were determined by thin-layer chromatography (TLC) with different solvent systems and by reversed-phase and polyamide layer techniques. Gas-liquid chromatographic (GLC) relative retention times were determined on different stationary phases with increasing polarity. Partition between n-octanol and water was determined using a GLC detection technique.

The partition data and cbromatographic properties were compared and correlated with physico~hemical linear free energy parameters for electronic, hydrophobic and steric forces. GLC partitioning is infhxenced by electronic and steric forces; whereas TLC partitioning is iniluenced by electronic and hydrophobic forces, depending on the polarity of the mobile phase.