Relationship of Hypolipidemic and Antineoplastic Activities of Tricyclohexyl- and Triphenylphosphine Boranes, Carboxyboranes, Cyanoboranes, and Related Derivatives

✍ Scribed by Mrinal K. Das; Pradip K. Maiti; Sarbari Roy; Malaiah Mittakanti; Karen W. Morse; Iris H. Hall

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 598 KB
• Volume: 325
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.19923250504

✦ Synopsis

A series of tricyclohexyland triphenylphosphine boranes, cahoxyboranes and cyanoboranes were synthesized These compounds have potent hypolipidemic effects, antineoplastic and antiinflammatory activities in rodents.

Furthermore, they demonstrated potent cyctotoxicity against standard human tissue culture lines. The compounds which afforded the best hypolipidemic activity, i.e. greater than 40% reduction of serum cholesterol and triglyceride levels, were diphenyl-(4-methylphenyl)-phosphine borane and triphenylphosphine carboxyborane. Other derivatives demonstrated mose potent antineoplastic activity against the Ehrfich ascites carcinoma growth including triphenylphosphine cyanoborane, 2-amino4methyl-pyridine cyanoborane and 2-aminepyridine cyanobome. Most of the derivatives showed good d v i t y against murine L1210 lymphoid leukemia, Tmolt3 human leukemia, uterine HeLa' cells. and human glioma cell growth. Select compounds were active against colon adenocarcinoma, KB na~~pharynx, lung hnchogemc and osteosarcoma cell growth. Tricyclohexyl-and triphenylphosphine boranes and the carboxy derivatives of the latter bomm demonstrated good antiintlammatory activity.