Relationship between subunit size and number of rare electrophoretic alleles in human enzymes

✍ Scribed by Walter F. Eanes; Richard K. Koehn

• Publisher: Springer
• Year: 1978
• Tongue: English
• Weight: 890 KB
• Volume: 16
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00483748

✦ Synopsis

Data from published sources were used to compare the numbers of different electrophoretic alleles of 29 monomeric and dimeric human enzymes to their respective subunit molecular weights. Only those human enzymes were considered for which the total sample sizes were in excess of 2000 individuals. Correlations between these two variables were determined within sample size ranges of 2000 less than or equal to n less than or equal to 3000 and 4000 less than or equal to n less than or equal to 5000 individuals, and separately by quaternary class. There was no statistically significant correlation observed for the smaller sample size range in monomers; however, the correlations for the larger sample size range in monomers and both ranges in dimers were significant. Since there is no relationship between subunit size and heterozygosity, the relationships are due primarily to the incidence of rare alleles. These findings demonstrate the effect of locus-specific mutation rates, expected as a consequence of variation of cistron sizes, and imply that other forces are responsible for the relative frequencies of common alleles at some of the loci.