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Relationship between lung tissue and blood plasma concentrations of inhaled budesonide

✍ Scribed by J. M. M. Van Den Bosch; C. J. J. Westermann; J. Aumann; S. Edsbácker; M. Tönnesson; O. Selroos

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
237 KB
Volume
14
Category
Article
ISSN
0142-2782

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✦ Synopsis

Abstract

In 11 patients, in whom a lung lobe or whole lung was to be resected, a single dose of 1.6 mg inhaled budesonide was given pre‐operatively. In 9 of them, concentrations of the drug in both lung tissue and blood plasma were measured. Budesonide concentrations in lung tissue, at least 90 min after dosage, were 2.1–8.9 nmol kg^−1^. Concentrations in blood plasma (0.27–1.1 nmol kg^−1^) were 1/8th of those in lung tissue.

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