Relationship between plasma and bone concentrations of cefuroxime and flucloxacillin three different parenteral administrations compared in 30 arthroplasties
✍ Scribed by Miguel M. Alvarez Ferrero; Dr. Tom B. Vree; Eleonora W J. Van Ewijk-Beneken Kolmer; Tom J. J. H. Slooff
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 473 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0142-2782
No coin nor oath required. For personal study only.
✦ Synopsis
i ) The objective was to determine the range of bone levels of cefuroxime and flucloxacillin achieved after one intravenous (IV) administration of different dosages of cefuroxime and flucloxacillin. (ii) Six groups of five patients participated in the study. The first three groups (A-C) received respectively 1500 mg, lo00 mg, and 500 mg cefuroxime intravenously and the second three groups (D-F) received 2000mg, 1500mg, and 1 W m g flucloxacillin intravenously. (iii) Parented administration of cefuroxime and flucloxacillin resulted in measurable bone concentrations in all patients. (iv) Large inter-individual variation in bone concentration was observed. (v) The bone concentrations of IV cefuroxime were higher (1500mg, p=O-0057; lo00 mg, p=O.O2aO) than those of flucloxacillin. The bone concentrations of cefuroxime and flucloxacillin were dose dependent.