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Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung


Book ID
123011632
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
155 KB
Volume
8
Category
Article
ISSN
0169-5002

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K-ras mutations in human adenocarcinoma
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## Abstract We investigated point mutational activation of the __ras__ genes (K‐__ras__ codons 12, 13 and 61; N‐__ras__ codons 12, 13 and 61; H‐__ras__ codons 12 and 61) in primary, resected lung cancer by dot blotting and oligonucleotide hybridization. K‐__ras__ mutations were found in 14 (29%) of