Relationship between IκBα constitutive expression, TNFα synthesis, and apoptosis in EBV-infected lymphoblastoid cells
✍ Scribed by Asso-Bonnet, Marianne; Feuillard, Jean; Ferreira, Valérie; Bissières, Philippe; Tarantino, Nadine; Körner, Marie; Raphael, Martine
- Book ID
- 110061821
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 843 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Development of chemoresistance in androgen‐refractory prostate cancer cells is partly due to constitutive activation of Rel/NF‐κB transcription factors that regulate several cell survival and anti‐apoptotic genes. In this study we examined whether betulinic acid (BetA), a pentacyclic tr
In response to a diverse array of signals, IkappaBalpha is targeted for phosphorylation-dependent degradation by the proteasome, thereby activating NF-kappaB. Here we demonstrate a role of the cleavage product of IkappaBalpha in various death signals. During apoptosis of NIH3T3, Jurkat, Rat-1, and L