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Relationship between histone acetylation/deacetylation and gene transcription

✍ Scribed by Zhen Lu; Yongchao Wang


Book ID
105641281
Publisher
Springer
Year
1998
Tongue
English
Weight
508 KB
Volume
43
Category
Article
ISSN
1001-6538

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Histone acetyltransferases and deacetylases can be targeted to promoters to activate or repress genes. For example, the histone acetyltransferase GCN5 is part of a yeast multiprotein complex that is recruited by the DNA-binding activator protein GCN4 (refs 1-3). The histone deacetylase RPD3 complex

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'The amino termini of histones extend from the nucleosomal core and are modified by acetyltransferases and deacetylases during the cell cycle. These acetylation patterns may direct histone assembly and help regulate the unfolding and activity of genes.