✦ LIBER ✦

Relationship Between Expression of Hepatitis B Virus Antigens in Isolated Hepatocytes and Autologous Lymphocyte Cytotoxicity in Patients with Chronic Hepatitis B Virus Infection

✍ Scribed by Nikolai V. Naumov; Mario Mondelli; Graeme J. M. Alexander; Richard S. Tedder; Adrian L. W. F. Eddleston; Roger Williams

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 721 KB
Volume: 4
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840040111

No coin nor oath required. For personal study only.

✦ Synopsis

Previous studies demonstrated that peripheral blood lymphocytes are cytotoxic to autologous hepatocytes in patients with chronic hepatitis B virus infection. We examined whether cytotoxicity is specifically directed against hepatocytes expressing HBsAg or HBcAg. Viral antigens were detected by immunofluorescence in isolated hepatocytes before and after exposure to T and non-T lymphocytes from 28 patients with chronic HBV infection in an autologous cytotoxicity assay.

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