𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Relationship between DNA ploidy, antigen expression and survival in renal cell carcinoma

✍ Scribed by E. Oosterwijk; S. O. Warnaar; J. Zwartendijk; E. A. Der Van Velde; G. J. Fleuren; C. J. Cornelisse

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
736 KB
Volume
42
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Tumor ploidy and expression of renal differentiation antigens as recognized by a previously described series of monoclonal antibodies (MAbs) (RCZ, RC3, RC4, RC38, RC69, RC154 and GZSO) were assessed in 48 renal-cell carcinomas. A positive association was found between aneuploidy and development of metastases. Aneuploid tumors showed a loss of antigen expression more frequently than diploid tumors. This difference was statistically significant for antigens recognized by RC3 and RC69. Loss of RCIS4 reactivity was associated with increased metastatic potential. Clinical stage was the most powerful single prognostic variable but ploidy and RC3 reactivity carried additional prognostic information.

πŸ“œ SIMILAR VOLUMES

Osteopontin expression correlates with p
Osteopontin expression correlates with prognostic variables and survival in clear cell renal cell carcinoma
✍ Koviljka Matusan; Gordana Dordevic; Darko Stipic; Vladimir Mozetic; Ksenija Luci πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 289 KB πŸ‘ 1 views

## Abstract ## Background and Objectives Osteopontin (OPN) is a phosphorylated glycoprotein with diverse functions including tumorigenesis and tumor cell metastasis. Recently, it has been detected in a growing number of human tumors, and assessed as a potential prognostic marker. The aim of this s

Relationship between sensitivity to natu
Relationship between sensitivity to natural killer cells and MHC class-I antigen expression in colon carcinoma cell lines
✍ HervΓ© M. BlottiΓ¨re; Rahima Zennadi; Cedric Burg; Jean-Yves Douillard; Khaled Mef πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 French βš– 588 KB

## Abstract The sensitivity of colorectal tumors to NK‐cell‐mediated cytotoxicity and their expression of major histocompatibility complex (MHC) class‐I antigens were studied in an attempt to determine whether such antigens play a role in the susceptibility of colorectal tumors to NK‐cell lysis. In

DNA content and prognosis in renal cell
DNA content and prognosis in renal cell carcinoma. A comparison between primary tumors and metastases
✍ BΓΆrje Ljungberg; Roger Stenling; GΓΆran Roos πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 English βš– 462 KB πŸ‘ 2 views

Deoxyribonucleic acid (DNA) content was retrospectively determined by single-cell cytophotometry in primary tumors and corresponding metastases from 32 patients with renal cell carcinoma. In 15 of the primary tumors a diploid/near diploid and in 17 an aneuploid DNA content was found. A diploid/near