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Relationship between DNA damage, DNA repair, metabolic state and cell lethality

✍ Scribed by Kenneth T. Wheeler; Robbie Hickman; Garret B. Nelson; Sarah K. Moore; C. Anne Wallen

Book ID
105119851
Publisher
Springer-Verlag
Year
1992
Tongue
English
Weight
963 KB
Volume
31
Category
Article
ISSN
0301-634X

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## Abstract DNA damage occurs in ischemia, excitotoxicity, inflammation, and other disorders that affect the central nervous system (CNS). Extensive DNA damage triggers cell death and in the mature CNS, this occurs primarily through activation of the poly(ADP‐ribose) polymerase‐1 (PARP‐1) cell deat