Relationship Between Changes in Bone Mineral Density and Vertebral Fracture Risk Associated With Risedronate
β Scribed by Watts, Nelson B.; Cooper, Cyrus; Lindsay, Robert; Eastell, Richard; Manhart, Michael D.; Barton, Ian P.; van Staa, Tjeerd-Pieter; Adachi, Jonathan D.
- Book ID
- 122973019
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 93 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1094-6950
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Dual-energy X-ray absorptiometric bone mineral density (DXA BMD) is a strong predictor of fracture risk in untreated patients. However, previous patient-level studies suggest that BMD changes explain little of the fracture risk reduction observed with osteoporosis treatment. We investigated the rele
## Abstract Surrogate markers of fracture riskβbone turnover markers (BTMs) and bone mineral density (BMD)βcan be used to monitor treatment response. We assessed whether changes in these markers greater than the least significant change (LSC) were associated with fracture risk reduction and greater