𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Relationship between bioavailability and hypocholesterolemic activity of YM17E, an inhibitor of ACAT, in cholesterol-fed rats

✍ Scribed by Taisuke Uchida; Kouji Aoyama; Takashi Watanabe; Saburo Higuchi

Book ID
119436505
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
143 KB
Volume
137
Category
Article
ISSN
0021-9150

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

The tolerability, pharmacokinetics and l
The tolerability, pharmacokinetics and lack of effect on plasma cholesterol of 447C88, an AcylCoA:Cholesterol Acyl Transferase (ACAT) inhibitor with low bioavailability, in healthy volunteers
✍ R. W. Peck; R. Wiggs; J. Posner πŸ“‚ Article πŸ“… 1995 πŸ› Springer 🌐 English βš– 657 KB

2 dimethylpropyl) phenyl)ethyl)phenyl)urea) is an inhibitor of human microsomal AcylCoA: Cholesterol acyltransferase (ACAT) with an ICs0 of 10.2 rig' m1-1 (23 nM). It is poorly absorbed but 5 mg. kg-1-daycompletely abolishes the rise in plasma cholesterol in cholesterol-fed rats. In this study, tw