๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

The tolerability, pharmacokinetics and effect on plasma cholesterol of 447C88, an ACAT inhibitor with low bioavailability, in healthy volunteers

โœ Scribed by R.W. Peck; R. Wiggs; J. Posner


Book ID
118325305
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
307 KB
Volume
109
Category
Article
ISSN
0021-9150

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


The tolerability, pharmacokinetics and l
โœ R. W. Peck; R. Wiggs; J. Posner ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Springer ๐ŸŒ English โš– 657 KB

2 dimethylpropyl) phenyl)ethyl)phenyl)urea) is an inhibitor of human microsomal AcylCoA: Cholesterol acyltransferase (ACAT) with an ICs0 of 10.2 rig' m1-1 (23 nM). It is poorly absorbed but 5 mg. kg-1-daycompletely abolishes the rise in plasma cholesterol in cholesterol-fed rats. In this study, tw

Effect of the ACAT inhibitor CI-976 on p
โœ Brian R. Krause; Richard F. Bousley; Karen A. Kieft; Richard L. Stanfield ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 724 KB

The overall objective of the present study was to determine if the ACAT inhibitor CI-976 can lower plasma cholesterol in hamsters fed zero or low, "human-like" levels of cholesterol. With a purified diet containing zero dietary cholesterol, CI-976 significantly lowered VLDL cholesterol (VLDL-C), but