2 dimethylpropyl) phenyl)ethyl)phenyl)urea) is an inhibitor of human microsomal AcylCoA: Cholesterol acyltransferase (ACAT) with an ICs0 of 10.2 rig' m1-1 (23 nM). It is poorly absorbed but 5 mg. kg-1-daycompletely abolishes the rise in plasma cholesterol in cholesterol-fed rats. In this study, tw
โฆ LIBER โฆ
The tolerability, pharmacokinetics and effect on plasma cholesterol of 447C88, an ACAT inhibitor with low bioavailability, in healthy volunteers
โ Scribed by R.W. Peck; R. Wiggs; J. Posner
- Book ID
- 118325305
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 307 KB
- Volume
- 109
- Category
- Article
- ISSN
- 0021-9150
No coin nor oath required. For personal study only.
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Effect of the ACAT inhibitor CI-976 on p
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Brian R. Krause; Richard F. Bousley; Karen A. Kieft; Richard L. Stanfield
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โ 724 KB
The overall objective of the present study was to determine if the ACAT inhibitor CI-976 can lower plasma cholesterol in hamsters fed zero or low, "human-like" levels of cholesterol. With a purified diet containing zero dietary cholesterol, CI-976 significantly lowered VLDL cholesterol (VLDL-C), but