Relapsing polychondritis: autoimmunity to type II collagen and treatment with cyclosporin A
β Scribed by A. ANSTEY; S. MAYOL; K. MORGAN; R.B. CLAGBE; D.D. MUNRO
- Book ID
- 108662101
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 1008 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0007-0963
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π SIMILAR VOLUMES
Objective. Joint inflammation in juvenile rheumatoid arthritis (JRA) is sometimes associated with an autoimmune response to type II collagen (CII), a cartilage-specific protein. To test the hypothesis that down-regulation of autoimmunity to CII can be accomplished in JRA by oral administration of CI
Objective. To characterize and clone T cells specific for type II collagen (CII) in a patient with relapsing polychondritis (RP) and to establish whether the immunodominant epitope of CII determined in HLA transgenic mice is used in the human autoimmune response to CII. Methods. T cell responses to
A heterozygous mutation in the COL2A1 gene was identified in a patient with hypochondrogenesis. The mutation was a single nucleotide transition of G3285T that resulted in an amino acid substitution of Cys for Gly9I3 in the al(I1) chain of type I1 collagen. This amino acid change disrupted the obliga