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Relapse of Hodgkin disease after extended-field radiotherapy

✍ Scribed by Horner, Richard J. ;Chaffey, John T. ;Rosenthal, David S. ;Moloney, William C.

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
309 KB
Volume
4
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

Thirteen relapses occurred among 51 consecutive surgically staged patients with I, IIA, and IIIA Hodgkin disease who achieved complete remission following extended‐field radiotherapy.

The median disease‐free interval was 14 months, but three disseminated relapses occurred at 36, 36, and 39 months. In 6 of the 13 cases, relapses occurred within treated fields. Relapse frequency was greater with advancing stage, but was not related to histology. In 9 of 12 evaluable cases the patients achieved complete remission with MOPPMOPP: mustargen, oncovin, procarbazine, prednisone (12).

combination chemotherapy. All responders continue in complete remission a median time of 23 months after completing MOPP.

This report emphasizes the need for sustained, close follow‐up after radical radiotherapy and the excellent response rate of relapsed patients to MOPP combination chemotherapy.

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