𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Reirradiation with intensity-modulated radiotherapy in recurrent head and neck cancer

✍ Scribed by Felix Zwicker; Falk Roeder; Henrik Hauswald; Christian Thieke; Carmen Timke; Wolfgang Schlegel; Juergen Debus; Marc W. Münter; Peter E. Huber

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
412 KB
Volume
33
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

In this retrospective investigation we analyzed outcome and toxicity after intensity‐modulated reirradiation of recurrent head and neck cancer.

Methods

Thirty‐eight patients with local recurrent head and neck cancer were evaluated. The median dose of initial radiotherapy was 61 Gy. Reirradiation was carried out with step‐and‐shoot intensity‐modulated radiotherapy (median dose: 49 Gy).

Results

Median overall survival was 17 months, and the 1‐ and 2‐year overall survival rates were 63% and 34%. The 1‐ and 2‐year local control rates were 57% and 53%. Distant spread occurred in 34%, and reirradiation induced considerable late toxicity in 21% of the patients. Thirty‐two percent showed increased xerostomia after reirradiation. The risk for xerostomia was significantly higher for cumulative mean doses of ≥45 Gy to parotid glands. Considering median cumulative maximum doses of 53 Gy to the spinal cord and 63 Gy to the brainstem, no late toxicities were observed.

Conclusions

Reirradiation with intensity‐modulated radiotherapy in recurrent head and neck cancer is feasible with acceptable toxicity and yields encouraging rates of local control and overall survival. © 2011 Wiley Periodicals, Inc. Head Neck, 2011

📜 SIMILAR VOLUMES

Efficacy and toxicity of reirradiation u
Efficacy and toxicity of reirradiation using intensity-modulated radiotherapy for recurrent or second primary head and neck cancer
✍ David J. Sher; Robert I. Haddad; Charles M. Norris Jr; Marshall R. Posner; Lori 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 169 KB 👁 1 views

## Abstract ## BACKGROUND: Patients with locally recurrent squamous cell cancer of the head and neck (SCCHN) are reported to have a poor prognosis and limited therapeutic options. Optimal management is selectively applied and morbid. Both surgical resection and chemoradiotherapy are reported to re

Outcomes following reirradiation of pati
Outcomes following reirradiation of patients with head and neck cancer
✍ David P. Goldstein; Lucy Hynds Karnell; Min Yao; G. Parker Chamberlin; Thanh X. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 128 KB 👁 2 views

## Abstract ## Background This study reports the outcomes for patients with head and neck cancer who received reirradiation with palliative or curative intent. ## Methods A retrospective review of 41 patients treated with curative (__n__ = 28) or palliative (__n__ = 13) reirradiation was conduct

Phase 1 trial of combined chemotherapy a
Phase 1 trial of combined chemotherapy and reirradiation for recurrent unresectable head and neck cancer
✍ Sharon Spencer; Richard Wheeler; Glenn Peters; Ruby Meredith; Sam Beenken; Lisle 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 78 KB 👁 1 views

## Abstract ## Background. The management of recurrent unresectable head and neck cancer remains a challenging problem. Based on the circadian rhythm concept, we sought to determine the maximum tolerated dose (MTD) of infusional 5‐flourouracil (5‐FU), hydroxyurea (HU), and reirradiation (RT). ##

Preoperative chemo-radiotherapy in advan
Preoperative chemo-radiotherapy in advanced head and neck cancer
✍ Pearlman, Nathan W. ;Meyers, Arlen D. ;Johnson, F. Bing ;Dibella, Nicholas J. 📂 Article 📅 1982 🏛 Wiley (John Wiley & Sons) ⚖ 451 KB 👁 1 views

## Abstract In a prospective evaluation, two preoperative courses of methotrexate, bleomycin, and cisplatin combined with 2,000 rad/10 fractions (“chemo‐radiotherapy”) yielded 78% response rates in previously untreated advanced head and neck cancer. Similarly staged patients receiving preoperative