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Preoperative chemo-radiotherapy in advanced head and neck cancer

✍ Scribed by Pearlman, Nathan W. ;Meyers, Arlen D. ;Johnson, F. Bing ;Dibella, Nicholas J.

Publisher
Wiley (John Wiley & Sons)
Year
1982
Weight
451 KB
Volume
5
Category
Article
ISSN
0148-6403

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✦ Synopsis

Abstract

In a prospective evaluation, two preoperative courses of methotrexate, bleomycin, and cisplatin combined with 2,000 rad/10 fractions (“chemo‐radiotherapy”) yielded 78% response rates in previously untreated advanced head and neck cancer. Similarly staged patients receiving preoperative irradiation of 5,000 rad alone had a 67% response rate. Treatment‐related mortality in the chemo‐radiotherapy patients was equal to that seen with standard combinations of surgery and preoperative or postoperative irradiation. At 24 months, disease‐free survival is 47% with chemo‐radiotherapy vs 33% with standard therapy; however, patients benefiting most from the former approach were those with T4 primary lesions or N3a neck nodes.

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