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Regulatory T Cells Require Serum for Suppression of Effector T Cell Proliferation and Express Stable Membrane-bound CD25

✍ Scribed by Todd Brusko; Clive Wasserfall; Kieran McGrail; Marcus Moore; Alyssa Huegel; Desmond Schatz; Mark Atkinson


Book ID
113539688
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
45 KB
Volume
123
Category
Article
ISSN
1090-2341

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CD28 and CTLA-4 are opposing regulators of T cell activation, triggered by the two ligands CD80 and CD86. How these ligands promote either T cell activation via CD28 or inhibition via CTLA-4 is not understood. Using CD80 and CD86 molecules expressed on transfected cells, we have identified a major d