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Regulatory role of microsomal 3-hydroxy-3-methylglutaryl-coenzyme a reductase in a tobacco mutant that overproduces sterols

✍ Scribed by Laurence Gondet; Thomas Weber; Pascale Maillot-Vernier; Pierre Benveniste; Thomas J. Bach


Book ID
115765092
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
424 KB
Volume
186
Category
Article
ISSN
0006-291X

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## Abstract Elevated 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase expression supports synthesis of prenyl pyrophosphate intermediates required for tumor growth. In this study, the copy number of HMG‐CoA reductase mRNA was determined in solid tumor and leukemic cell lines using competit