Regulation of Xenobiotic Detoxification by Nuclear Receptors
โ Scribed by JM Pascussi; S Gerbal-Chaloin; L Drocourt; L Pichard-Garcia; MJ Vilarem; P Maurel
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 437 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1054-2523
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
In the past year, additional experimental data have expanded our understanding of the molecular mechanisms that underlie nuclear receptor control of regulatory programs. It is increasingly clear that steroid members (e.g. glucocorticoid and estrogen) and non-steroid members (e.g. retinoic acid, thyr
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are implicated in xenobiotic and endobiotic detoxification, including the clearance of toxic bilirubin. Previous studies have suggested both overlapping and preferential regulation of target genes by these receptors, but th