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Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis

✍ Scribed by Angela L. Slitt; Katryn Allen; Jennifer Morrone; Lauren M. Aleksunes; Chuan Chen; Jonathan M. Maher; José E. Manautou; Nathan J. Cherrington; Curtis D. Klaassen


Book ID
116274351
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
805 KB
Volume
1768
Category
Article
ISSN
0005-2736

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The liver plays a major role in biotransformation and elimination of various therapeutic agents and xenobiotics, many of which are organic cations and substrates of the organic cation transporter 1 (Oct1, Slc22a1). Oct1 is expressed at the basolateral membranes of hepatocytes and proximal renal tubu