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Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1

✍ Scribed by Gregg L. Semenza

Book ID: 110109805
Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 485 KB
Volume: 92
Category: Article
ISSN: 0958-0670
DOI: 10.1113/expphysiol.2006.036343

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## Abstract Hypoxia and induction of hypoxia‐inducible factors (HIF‐1α and HIF‐2α) is a hallmark of many tumors. Under normal oxygen tension HIF‐alpha subunits are rapidly degraded through prolyl hydroxylase dependent interaction with the von Hippel‐Lindau (VHL) tumor suppressor protein, a componen