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Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase

✍ Scribed by Tomas Mustelin; Tiina Pessa-Morikawa; Matti Autero; Martin Gassmann; Leif C. Andersson; Carl G. Gahmberg; Paul Burn


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
687 KB
Volume
22
Category
Article
ISSN
0014-2980

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Modulation of the phagocyte protein tyrosine phosphatase (PTP) SHP-1 by the parasite Leishmania favors its survival and propagation within its mammalian host. In vivo, the absence of SHP-1 leads to virtually absent footpad swelling, accompanied by enhanced inducible nitric oxide synthase expression.