✦ LIBER ✦

Regulation of the p53 transcriptional activity

✍ Scribed by Gang Liu; Xinbin Chen

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 116 KB
Volume: 97
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.20700

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✦ Synopsis

Abstract

In response to various stresses, p53 is rapidly activated and transcriptionally regulates a number of target genes by which p53 modulates a variety of cellular activities. The transcriptional activity of p53 is delicately regulated by a plethora of cellular factors, independently or synergistically, in multiple ways in order to achieve a specific response. This article reviewed the role of the basal transcriptional machinery, co‐activators, and co‐repressors involved in p53‐dependent transcription, and the underlying mechanism by which the p53 transcriptional activity is regulated. We also discussed some potentially interesting questions and future directions in the field. J. Cell. Biochem. © 2005 Wiley‐Liss, Inc.

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