## Abstract In response to various stresses, p53 is rapidly activated and transcriptionally regulates a number of target genes by which p53 modulates a variety of cellular activities. The transcriptional activity of p53 is delicately regulated by a plethora of cellular factors, independently or syn
p53 regulates thymic Notch1 activation
✍ Scribed by Amy M. Laws; Barbara A. Osborne
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 229 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The tumor suppressor, p53, has been shown to transcriptionally activate or silence a number of target genes. As an activator, p53 relies on its specific consensus sequence within the promoter. It is not clear whether p53 requires a specific DNA binding site in its action as a gene repre
The conserved region 1 and the extreme N-terminus of adenoviral oncoprotein E1A are essential for transforming activity. They also play roles in the interaction of E1A with p300/CBP and pRb and are involved in both transactivation and repression of host gene expression. It was reported recently that
## Abstract Exposure of mammalian cells to genotoxic stress results in activation of the c‐jun amino‐terminal kinase (JNK)‐stress‐activated protein kinase (SAPK) pathway and induction of DNA repair enzymes and cell cycle–regulatory proteins such as p53 and __p21waf1__. The p53 tumor suppressor prot
## Abstract __p53__, a tumor suppressor gene involved in the G1 cell cycle checkpoint, is also the most frequently mutated gene in human cancer. In addition, p53 modifies the ability of tumor cells to metastasize. The metastasis‐associated gene __Nm23‐H1__, which encodes an 18‐kDa nucleoside diphos
## Abstract We have previously reported that human matrix metalloproteinase‐1 (MMP1) is a __p53__ target gene subject to down‐regulation (Sun et al. [1999]: J Biol Chem 274:11535–11540]. In the present study, we demonstrate that the down‐regulation of the human −83MMP1 promoter fragment by p53 was