Regulation of the immune response in autoimmune NZB/NZW F1 mice: I. The spontaneous generation of splenic suppressor cells
β Scribed by John C. Roder; David A. Bell; Sharwan K. Singhal
- Book ID
- 115811335
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 904 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0008-8749
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π SIMILAR VOLUMES
The NZB x NZW F1 mxce spontaneously develop autoimmune disease resembling human systemic lupus erythematosus (SLE). This disease is characterized by severe lupus nephritis, which develops in close association with the production of IgG class autoantibodies to double-stranded (ds) DNA and histones (S
Natural killer T (NKT) cells and CD5(+)B cells were searched for in various immune organs of autoimmune prone (NZBxNZW)F(1) (NZB/W F(1)) mice. The number of lymphocytes increased in the liver, spleen, and peritoneal cavity after the onset of disease (at the age of 30 weeks) while the number of thymo